Epidemiological Study on β-Thalassemia in Algeria

Genomic Study in β - Thalassemia

Epidemiological Investigation of a Twenty-Year Major β-Thalassemia Surveillance in Kerman, Iran

Background & Aims of the Study: Since beta-thalassemia is the most commonly inherited disease in Iran, its preventive and controlling programs are considered vitally important in the healthcare system. This study was conducted to investigate the incidence rate and epidemiology of major beta-thalassemia (MBT) over the last twenty years in Kerman, Iran. Materials and Methods: This cross-secti...

The incidence of alpha-thalassemia in Setif, Algeria.

Thalassemias are hereditary anemia syndromes occurring due to erroneous producing of globin chain of hemoglobin. Thalassemia syndromes are named according to the type of the affected globin chain. The most common types of thalassemia are alpha thalassemia and beta thalassemia. In α-thalassemia, α-globin chain production is either by decreased or completely disappeared. The gene encoding the α-g...

Therapeutic approaches in patients with β-thalassemia

Beta-thalassemia (β-thal) is a congenital hemoglobinopathy explained by a decreased level (β+) or absence (βο) of β-globin gene expression. Microcytic hypochromic anemia and various clinical symptoms comprising severe anemia to clinically nonsymptomatic features. Treatment with an ordered blood transfusion and iron chelator agents can decrease transfusion iron overload that causes normal matura...

Transfusion-Transmitted Viruses in Individuals with β Thalassemia Major at Northeastern Iran, a Retrospective Sero-Epidemiological Survey

Background: Thalassemia syndromes are the most common genetic disorders in the world. They happen due to genetic defects in process of haemoglobin synthesis, and would be classified to many groups mainly α and β, based on the kind of defect. Anemia is the main clinical manifestation of this phenotype of disorder. In order to correct the chronic anemia in thalassaemic individuals, they may need ...